New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Trypanosoma Protease Rhodesain

Electrophilic (het)arenes can undergo reactions with nucleophiles yielding π- or Meisenheimer (σ-) complexes or the products of the S(N)Ar addition/elimination reactions. Such building blocks have only rarely been employed for the design of enzyme inhibitors. Herein, we demonstrate the combination o...

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Publié dans:Molecules
Auteurs principaux: Klein, Philipp, Johe, Patrick, Wagner, Annika, Jung, Sascha, Kühlborn, Jonas, Barthels, Fabian, Tenzer, Stefan, Distler, Ute, Waigel, Waldemar, Engels, Bernd, Hellmich, Ute A., Opatz, Till, Schirmeister, Tanja
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145299/
https://ncbi.nlm.nih.gov/pubmed/32210166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25061451
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