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New Peptide-Based Pharmacophore Activates 20S Proteasome

The proteasome is a pivotal element of controlled proteolysis, responsible for the catabolic arm of proteostasis. By inducing apoptosis, small molecule inhibitors of proteasome peptidolytic activities are successfully utilized in treatment of blood cancers. However, the clinical potential of proteas...

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Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Osmulski, Paweł A., Karpowicz, Przemysław, Jankowska, Elżbieta, Bohmann, Jonathan, Pickering, Andrew M., Gaczyńska, Maria
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145288/
https://ncbi.nlm.nih.gov/pubmed/32235805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25061439
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