Site-specific proteolytic cleavage prevents ubiquitination and degradation of human REV3L, the catalytic subunit of DNA polymerase ζ

REV3L, the catalytic subunit of DNA polymerase ζ (Pol ζ), is indispensable for translesion DNA synthesis, which protects cells from deleterious DNA lesions resulting from various intrinsic and environmental sources. However, REV3L lacks a proofreading exonuclease activity and consequently bypasses D...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Wang, Fengting, Li, Pan, Shao, Yuan, Li, Yanyan, Zhang, Kai, Li, Miaomiao, Wang, Rong, Zheng, Shuo, Wang, Yingying, Song, Sen, Feng, Shiguo, Liu, Fei, Xiao, Wei, Li, Xialu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144948/
https://ncbi.nlm.nih.gov/pubmed/32064513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa096
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