Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH

All enzymes face a challenge of discriminating cognate substrates from similar cellular compounds. Finding a correct substrate is especially difficult for the Escherichia coli Nudix hydrolase RppH, which triggers 5′-end-dependent RNA degradation by removing orthophosphate from the 5′-diphosphorylate...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Gao, Ang, Vasilyev, Nikita, Kaushik, Abhishek, Duan, Wenqian, Serganov, Alexander
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
RNA and RNA-protein complexes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144940/
https://ncbi.nlm.nih.gov/pubmed/31960065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa024
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