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Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5′-End-dependent mRNA Decay

5′-End-dependent RNA degradation impacts virulence, stress responses, and DNA repair in bacteria by controlling the decay of hundreds of mRNAs. The RNA pyrophosphohydrolase RppH, a member of the Nudix hydrolase superfamily, triggers this degradation pathway by removing pyrophosphate from the triphos...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Vasilyev, Nikita, Serganov, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392254/
https://ncbi.nlm.nih.gov/pubmed/25657011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634824
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