Raltegravir (RAL) in neonates: Dosing, pharmacokinetics (PK), and safety in HIV-1 exposed neonates at risk of infection (IMPAACT P1110)

BACKGROUND: Adequate pharmacokinetic and safety data in neonates are lacking for most antiretroviral agents. Raltegravir is a selective HIV-1 integrase strand transfer inhibitor (INSTI) available in a granule formulation suitable for use in neonates and young infants as prophylaxis or treatment of H...

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Udgivet i:J Acquir Immune Defic Syndr
Main Authors: Clarke, Diana F., Acosta, Edward P., Cababasay, Mae, Wang, Jiajia, Chain, Anne, Teppler, Hedy, Popson, Stephanie, Graham, Bobbie, Smith, Betsy, Hazra, Rohan, Calabrese, Kat, Bryson, Yvonne, Spector, Stephen A., Lommerse, Jos, Mirochnick, Mark
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144886/
https://ncbi.nlm.nih.gov/pubmed/31913995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000002294
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