Mutation position is an important determinant for predicting cancer neoantigens

Tumor-specific mutations can generate neoantigens that drive CD8 T cell responses against cancer. Next-generation sequencing and computational methods have been successfully applied to identify mutations and predict neoantigens. However, only a small fraction of predicted neoantigens are immunogenic...

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Publicat a:J Exp Med
Autors principals: Capietto, Aude-Hélène, Jhunjhunwala, Suchit, Pollock, Samuel B., Lupardus, Patrick, Wong, Jim, Hänsch, Lena, Cevallos, James, Chestnut, Yajun, Fernandez, Ajay, Lounsbury, Nicolas, Nozawa, Tamaki, Singh, Manmeet, Fan, Zhiyuan, de la Cruz, Cecile C., Phung, Qui T., Taraborrelli, Lucia, Haley, Benjamin, Lill, Jennie R., Mellman, Ira, Bourgon, Richard, Delamarre, Lélia
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144530/
https://ncbi.nlm.nih.gov/pubmed/31940002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190179
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