Mutation position is an important determinant for predicting cancer neoantigens

Tumor-specific mutations can generate neoantigens that drive CD8 T cell responses against cancer. Next-generation sequencing and computational methods have been successfully applied to identify mutations and predict neoantigens. However, only a small fraction of predicted neoantigens are immunogenic...

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Udgivet i:J Exp Med
Main Authors: Capietto, Aude-Hélène, Jhunjhunwala, Suchit, Pollock, Samuel B., Lupardus, Patrick, Wong, Jim, Hänsch, Lena, Cevallos, James, Chestnut, Yajun, Fernandez, Ajay, Lounsbury, Nicolas, Nozawa, Tamaki, Singh, Manmeet, Fan, Zhiyuan, de la Cruz, Cecile C., Phung, Qui T., Taraborrelli, Lucia, Haley, Benjamin, Lill, Jennie R., Mellman, Ira, Bourgon, Richard, Delamarre, Lélia
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144530/
https://ncbi.nlm.nih.gov/pubmed/31940002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190179
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