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Magnoflorine Suppresses MAPK and NF-κB Signaling to Prevent Inflammatory Osteolysis Induced by Titanium Particles In Vivo and Osteoclastogenesis via RANKL In Vitro

Wear particles that detach from the surface of prostheses induce excessive activation of osteoclast and immoderate release of inflammatory cytokines that lead to peri-implant osteolysis and aseptic loosening. In this work, we investigated whether magnoflorine, a quaternary aporphine alkaloid extract...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Sun, Zhenyu, Zeng, Junkai, Wang, Wenjuan, Jia, Xinlin, Wu, Qiang, Yu, Degang, Mao, Yuanqing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142243/
https://ncbi.nlm.nih.gov/pubmed/32300300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00389
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