Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo

Excessive bone resorption by osteoclasts contributes significantly to osteoclast-related diseases such as periprosthetic osteolysis and osteoporosis. Osteolysis in a titanium particle-induced calvarial model and bone loss in an ovariectomized mice model occurred similarly to those in humans; thus, t...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Xu, Qiang, Chen, Guiping, Xu, Huaen, Xia, Guoming, Zhu, Meisong, Zhan, Haibo, Zhang, Bin, Dai, Min, Fan, Hongxian, Liu, Xuqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210420/
https://ncbi.nlm.nih.gov/pubmed/34149427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.682541
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