Lycorine suppresses RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced osteoporosis and titanium particle-induced osteolysis in vivo

Osteoclasts play an important role in diseases involving bone loss. In this study, we assessed the effect of a plant-derived natural alkaloid (lycorine, or LY) on osteoclastogenesis in vitro and in vivo. Our in vitro study showed that receptor activator of nuclear factor-κB ligand (RANKL)-induced os...

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Pubblicato in:Sci Rep
Autori principali: Chen, Shuai, Jin, Gu, Huang, Kang-Mao, Ma, Jian-Jun, Wang, Qiang, Ma, Yan, Tang, Xiao-Zhen, Zhou, Zhi-Jie, Hu, Zhi-Jun, Wang, Ji-Ying, Qin, An, Fan, Shun-Wu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523876/
https://ncbi.nlm.nih.gov/pubmed/26238331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12853
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