Jatrorrhizine Hydrochloride Suppresses RANKL-Induced Osteoclastogenesis and Protects against Wear Particle-Induced Osteolysis

Wear particle-induced aseptic prosthetic loosening is a major complication associated with total joint arthroplasty (TJA). A growing body of evidence suggests that receptor activator of nuclear factor κ-B ligand (RANKL)-stimulated osteoclastogenesis and bone resorption are responsible for p...

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Autors principals: Hui Li, Jing Wang, Qiwen Sun, Gang Chen, Shengnan Sun, Xuemei Ma, Haiwen Qiu, Xuerong Liu, Liangyi Xu, Mei Liu
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2018-11-01
Col·lecció:International Journal of Molecular Sciences
Matèries:
jatrorrhizine hydrochloride
osteoclast formation
bone resorption
wear particle-induced osteolysis
MAPK signaling pathway
Accés en línia:https://www.mdpi.com/1422-0067/19/11/3698
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