20(S)-Protopanaxadiol Inhibits Titanium Particle-Induced Inflammatory Osteolysis and RANKL-Mediated Osteoclastogenesis via MAPK and NF-κB Signaling Pathways

Osteolysis is a principal reason for arthroplasty failure like aseptic loosening induced by Titanium (Ti) particle. It is a challenge for orthopedic surgeons. Recent researches show that 20(S)-protopanaxadiol can inhibit inflammatory cytokine release in vitro. This study aims to assess the effect of...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Pan, Chenhao, Shan, Haojie, Wu, Tianyi, Liu, Wei, Lin, Yiwei, Xia, Wenyang, Wang, Feng, Zhou, Zubin, Yu, Xiaowei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345703/
https://ncbi.nlm.nih.gov/pubmed/30713497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01538
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