Magnoflorine Suppresses MAPK and NF-κB Signaling to Prevent Inflammatory Osteolysis Induced by Titanium Particles In Vivo and Osteoclastogenesis via RANKL In Vitro

Wear particles that detach from the surface of prostheses induce excessive activation of osteoclast and immoderate release of inflammatory cytokines that lead to peri-implant osteolysis and aseptic loosening. In this work, we investigated whether magnoflorine, a quaternary aporphine alkaloid extract...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Sun, Zhenyu, Zeng, Junkai, Wang, Wenjuan, Jia, Xinlin, Wu, Qiang, Yu, Degang, Mao, Yuanqing
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142243/
https://ncbi.nlm.nih.gov/pubmed/32300300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00389
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