A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma

PURPOSE: Although most children with medulloblastoma are cured of their disease, Sonic Hedgehog (SHH) subgroup medulloblastoma driven by TRP53 mutations is essentially lethal. Casein kinase 1a (CK1α) phosphorylates and destabilizes GLI transcription factors, thereby inhibiting the key effectors of S...

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Pubblicato in:Clin Cancer Res
Autori principali: Rodriguez-Blanco, Jezabel, Li, Bin, Long, Jun, Shen, Chen, Yang, Fan, Orton, Darren, Collins, Sara, Kasahara, Noriyuki, Ayad, Nagi G., McCrea, Heather J., Roussel, Martine F., Weiss, William A., Capobianco, Anthony J., Robbins, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142219/
https://ncbi.nlm.nih.gov/pubmed/30487124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1319
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