Phosphorylation independent eIF4E translational reprogramming of selective mRNAs determines tamoxifen resistance in breast cancer

Eukaryotic translation initiation factor 4E (eIF4E) selectively promotes translation of mRNAs with atypically long and structured 5′-UTRs and has been implicated in drug resistance. Through genome-wide transcriptome and translatome analysis we revealed eIF4E overexpression could promote cellular act...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Gong, Chun, Tsoi, Ho, Mok, Ka Chun, Cheung, Jenny, Man, Ellen P. S., Fujino, Kazunari, Wong, Ashely, Lam, Eric W. F., Khoo, Ui-Soon
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142019/
https://ncbi.nlm.nih.gov/pubmed/32066877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1210-y
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