Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming

The majority of breast cancers expresses the estrogen receptor (ER(+)) and is treated with anti-estrogen therapies, particularly tamoxifen in premenopausal women. However, tamoxifen resistance is responsible for a large proportion of breast cancer deaths. Using small molecule inhibitors, phospho-mim...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Geter, Phillip A., Ernlund, Amanda W., Bakogianni, Sofia, Alard, Amandine, Arju, Rezina, Giashuddin, Shah, Gadi, Abhilash, Bromberg, Jacqueline, Schneider, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769768/
https://ncbi.nlm.nih.gov/pubmed/29269484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.305631.117
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