ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells

ZBTB7A is frequently mutated in acute myeloid leukemia (AML) with t(8;21) translocation. However, the oncogenic collaboration between mutated ZBTB7A and the RUNX1–RUNX1T1 fusion gene in AML t(8;21) remains unclear. Here, we investigate the role of ZBTB7A and its mutations in the context of normal an...

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Publicat a:Oncogene
Autors principals: Redondo Monte, Enric, Wilding, Anja, Leubolt, Georg, Kerbs, Paul, Bagnoli, Johannes W., Hartmann, Luise, Hiddemann, Wolfgang, Chen-Wichmann, Linping, Krebs, Stefan, Blum, Helmut, Cusan, Monica, Vick, Binje, Jeremias, Irmela, Enard, Wolfgang, Theurich, Sebastian, Wichmann, Christian, Greif, Philipp A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142018/
https://ncbi.nlm.nih.gov/pubmed/32115572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1209-4
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