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TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models
Genetic redundancy can be exploited to identify therapeutic targets for inherited disorders. We explored this possibility in DYT1 dystonia, a neurodevelopmental movement disorder caused by a loss-of-function (LOF) mutation in the TOR1A gene encoding torsinA. Prior work demonstrates that torsinA and...
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| Publicado en: | eLife |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7141835/ https://ncbi.nlm.nih.gov/pubmed/32202496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54285 |
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