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Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia

Multiple lines of evidence implicate striatal dysfunction in the pathogenesis of dystonia, including in DYT1, a common inherited form of the disease. The impact of striatal dysfunction on connected motor circuits and their interaction with other brain regions is poorly understood. Conditional knock-...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neurobiol Dis
Main Authors: DeSimone, Jesse C., Pappas, Samuel S., Febo, Marcelo, Burciu, Roxana G., Shukla, Priyank, Colon-Perez, Luis M., Dauer, William T., Vaillancourt, David E.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555738/
https://ncbi.nlm.nih.gov/pubmed/28673740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.06.015
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