Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons

Striatal dysfunction plays an important role in dystonia, but the striatal cell types that contribute to abnormal movements are poorly defined. We demonstrate that conditional deletion of the DYT1 dystonia protein torsinA in embryonic progenitors of forebrain cholinergic and GABAergic neurons causes...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Pappas, Samuel S, Darr, Katherine, Holley, Sandra M, Cepeda, Carlos, Mabrouk, Omar S, Wong, Jenny-Marie T, LeWitt, Tessa M, Paudel, Reema, Houlden, Henry, Kennedy, Robert T, Levine, Michael S, Dauer, William T
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473728/
https://ncbi.nlm.nih.gov/pubmed/26052670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08352
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