Kinome Profiling of NF1-Related MPNSTs in Response to Kinase Inhibition and Doxorubicin Reveals Therapeutic Vulnerabilities

Neurofibromatosis Type 1 (NF1)-related Malignant Peripheral Nerve Sheath Tumors (MPNST) are highly resistant sarcomas that account for significant mortality. The mechanisms of therapy resistance are not well-understood in MPNSTs, particularly with respect to kinase inhibition strategies. In this stu...

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Pubblicato in:Genes (Basel)
Autori principali: Grit, Jamie L., Pridgeon, Matt G., Essenburg, Curt J., Wolfrum, Emily, Madaj, Zachary B., Turner, Lisa, Wulfkuhle, Julia, Petricoin, Emanuel F., Graveel, Carrie R., Steensma, Matthew R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141129/
https://ncbi.nlm.nih.gov/pubmed/32245042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11030331
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