NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer

The key negative regulatory gene of the RAS pathway, NF1, is mutated or deleted in numerous cancer types and is associated with increased cancer risk and drug resistance. Even though women with neurofibromatosis (germline NF1 mutations) have a substantially increased breast cancer risk at a young ag...

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Detalhes bibliográficos
Publicado no:NPJ Breast Cancer
Main Authors: Dischinger, Patrick S., Tovar, Elizabeth A., Essenburg, Curt J., Madaj, Zachary B., Gardner, Eve E., Callaghan, Megan E., Turner, Ashley N., Challa, Anil K., Kempston, Tristan, Eagleson, Bryn, Kesterson, Robert A., Bronson, Roderick T., Bowman, Megan J., Graveel, Carrie R., Steensma, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117327/
https://ncbi.nlm.nih.gov/pubmed/30182054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-018-0080-8
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