Genomic status of MET potentiates sensitivity to MET and MEK inhibition in NF1-related malignant peripheral nerve sheath tumors

Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are highly resistant sarcomas that occur in up to 13% of individuals with Neurofibromatosis Type 1 (NF1). Genomic analysis of longitudinally collected tumor samples in a case of MPNST disease progression revealed early hemizygous microdeletions in NF...

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Publicado no:Cancer Res
Main Authors: Peacock, Jacqueline D., Pridgeon, Matthew G., Tovar, Elizabeth A., Essenburg, Curt J., Bowman, Megan, Madaj, Zachary, Koeman, Julie, Boguslawski, Elissa A., Grit, Jamie, Dodd, Rebecca D., Khachaturov, Vadim, Cardona, Diana M., Chen, Mark, Kirsch, David G., Maina, Flavio, Dono, Rosanna, Winn, Mary E., Graveel, Carrie R., Steensma, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235171/
https://ncbi.nlm.nih.gov/pubmed/29720369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3167
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