Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling

Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity and mortality in NF1. Cutaneous (CNF) and plexiform neurofibromas (PNF) share nearly identical histology, but maintain different growth rates and risk of malignant conv...

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Bibliografiske detaljer
Udgivet i:Epigenetics Chromatin
Main Authors: Grit, Jamie L., Johnson, Benjamin K., Dischinger, Patrick S., J. Essenburg, Curt, Adams, Marie, Campbell, Stacy, Pollard, Kai, Pratilas, Christine A., Triche, Tim J., Graveel, Carrie R., Steensma, Matthew R.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7805211/
https://ncbi.nlm.nih.gov/pubmed/33436083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-020-00380-6
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