Mesenchymal Stem Cell-Specific and Preosteoblast-Specific Ablation of TSC1 in Mice Lead to Severe and Slight Spinal Dysplasia, Respectively

BACKGROUND: TSC1-related signaling plays a pivotal role in intramembranous and endochondral ossification processes during skeletogenesis. This study was aimed at determining the significance of the TSC1 gene at different stages of spinal development. Materials and Methods. TSC1-floxed mice (TSC1(flo...

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Vydáno v:Biomed Res Int
Hlavní autoři: Yang, Cheng, Liao, Jianwen, Lai, Pinglin, Huang, Hai, Fan, Shicai, Chen, Yuhui, Bai, Xiaochun
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140121/
https://ncbi.nlm.nih.gov/pubmed/32309432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/4572687
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