Mesenchymal Stem Cell-Specific and Preosteoblast-Specific Ablation of TSC1 in Mice Lead to Severe and Slight Spinal Dysplasia, Respectively

BACKGROUND: TSC1-related signaling plays a pivotal role in intramembranous and endochondral ossification processes during skeletogenesis. This study was aimed at determining the significance of the TSC1 gene at different stages of spinal development. Materials and Methods. TSC1-floxed mice (TSC1(flo...

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Detalles Bibliográficos
Publicado en:Biomed Res Int
Main Authors: Yang, Cheng, Liao, Jianwen, Lai, Pinglin, Huang, Hai, Fan, Shicai, Chen, Yuhui, Bai, Xiaochun
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140121/
https://ncbi.nlm.nih.gov/pubmed/32309432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/4572687
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