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Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification

Intratumour heterogeneity fuels carcinogenesis and allows circumventing specific targeted therapies. HER2 gene amplification is associated with poor outcome in invasive breast cancer. Heterogeneous HER2 amplification has been described in 5–41% of breast cancers. Here, we investigated the genetic di...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Oncol
Hauptverfasser: Van Bockstal, Mieke R., Agahozo, Marie Colombe, van Marion, Ronald, Atmodimedjo, Peggy N., Sleddens, Hein F. B. M., Dinjens, Winand N. M., Visser, Lindy L., Lips, Esther H., Wesseling, Jelle, van Deurzen, Carolien H. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138394/
https://ncbi.nlm.nih.gov/pubmed/32058674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12650
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