Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification

Intratumour heterogeneity fuels carcinogenesis and allows circumventing specific targeted therapies. HER2 gene amplification is associated with poor outcome in invasive breast cancer. Heterogeneous HER2 amplification has been described in 5–41% of breast cancers. Here, we investigated the genetic di...

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Main Authors: Mieke R. Van Bockstal, Marie Colombe Agahozo, Ronald van Marion, Peggy N. Atmodimedjo, Hein F. B. M. Sleddens, Winand N. M. Dinjens, Lindy L. Visser, Esther H. Lips, Jelle Wesseling, Carolien H. M. van Deurzen
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2020-04-01
Colecção:Molecular Oncology
Assuntos:
breast cancer
copy number variations
HER2 amplification
intratumour heterogeneity
next‐generation sequencing
somatic mutation
Acesso em linha:https://doi.org/10.1002/1878-0261.12650
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