Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43

A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation of TARDBP/TDP-43 (TAR DNA binding protein). We previously showed that the ability of TARDBP to repress nonconserved cryptic exons was impaired...

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Bibliografske podrobnosti
izdano v:Autophagy
Main Authors: Donde, Aneesh, Sun, Mingkuan, Jeong, Yun Ha, Wen, Xinrui, Ling, Jonathan, Lin, Sophie, Braunstein, Kerstin, Nie, Shuke, Wang, Sheng, Chen, Liam, Wong, Philip C.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2019
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138241/
https://ncbi.nlm.nih.gov/pubmed/31242080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1635379
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