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Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model
TDP-43 proteinopathy, initially associated with ALS and FTD, is also found in 30–60% of Alzheimer's disease (AD) cases and correlates with worsened cognition and neurodegeneration. A major component of this proteinopathy is depletion of this RNA-binding protein from the nucleus, which compromis...
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| Publicado no: | Acta Neuropathol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5131701/ https://ncbi.nlm.nih.gov/pubmed/27785573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1637-y |
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