Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model

TDP-43 proteinopathy, initially associated with ALS and FTD, is also found in 30–60% of Alzheimer's disease (AD) cases and correlates with worsened cognition and neurodegeneration. A major component of this proteinopathy is depletion of this RNA-binding protein from the nucleus, which compromis...

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Bibliographic Details
Published in:Acta Neuropathol
Main Authors: LaClair, Katherine D., Donde, Aneesh, Ling, Jonathan P., Jeong, Yun Ha, Chhabra, Resham, Martin, Lee J., Wong, Philip C.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131701/
https://ncbi.nlm.nih.gov/pubmed/27785573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1637-y
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