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Splicing Repression is a Major Function of TDP-43 in Motor Neurons

Nuclear depletion of TDP-43, an essential RNA binding protein, may underlie neurodegeneration in amyotrophic lateral sclerosis (ALS). As several functions have been ascribed to this protein, the critical role(s) of TDP-43 in motor neurons that may be compromised in ALS remains unknown. We show here...

詳細記述

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書誌詳細
出版年:Acta Neuropathol
主要な著者: Donde, Aneesh, Sun, Mingkuan, Ling, Jonathan P., Braunstein, Kerstin E., Pang, Bo, Wen, Xinrui, Cheng, Xueying, Chen, Liam, Wong, Philip C.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802294/
https://ncbi.nlm.nih.gov/pubmed/31332509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02042-8
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