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FBXO22 degrades nuclear PTEN to promote tumorigenesis
Nuclear localization of PTEN is essential for its tumor suppressive role, and loss of nuclear PTEN is more prominent than cytoplasmic PTEN in many kinds of cancers. However, nuclear PTEN-specific regulatory mechanisms were rarely reported. Based on the finding that nuclear PTEN is more unstable than...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7136256/ https://ncbi.nlm.nih.gov/pubmed/32249768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15578-1 |
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