FBXO22 degrades nuclear PTEN to promote tumorigenesis

Nuclear localization of PTEN is essential for its tumor suppressive role, and loss of nuclear PTEN is more prominent than cytoplasmic PTEN in many kinds of cancers. However, nuclear PTEN-specific regulatory mechanisms were rarely reported. Based on the finding that nuclear PTEN is more unstable than...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Ge, Meng-Kai, Zhang, Na, Xia, Li, Zhang, Cheng, Dong, Shuang-Shu, Li, Zhan-Ming, Ji, Yan, Zheng, Min-Hua, Sun, Jing, Chen, Guo-Qiang, Shen, Shao-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136256/
https://ncbi.nlm.nih.gov/pubmed/32249768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15578-1
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