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Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis
Tumor suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) levels are frequently found reduced in human cancers, but how PTEN is down-regulated is not fully understood. In addition, although a compelling connection exists between PRL (phosphatase of regenerating liver) 2 and c...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7456095/ https://ncbi.nlm.nih.gov/pubmed/32788364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002964117 |
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