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FBXO22 degrades nuclear PTEN to promote tumorigenesis

Nuclear localization of PTEN is essential for its tumor suppressive role, and loss of nuclear PTEN is more prominent than cytoplasmic PTEN in many kinds of cancers. However, nuclear PTEN-specific regulatory mechanisms were rarely reported. Based on the finding that nuclear PTEN is more unstable than...

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Publicado en:Nat Commun
Main Authors: Ge, Meng-Kai, Zhang, Na, Xia, Li, Zhang, Cheng, Dong, Shuang-Shu, Li, Zhan-Ming, Ji, Yan, Zheng, Min-Hua, Sun, Jing, Chen, Guo-Qiang, Shen, Shao-Ming
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136256/
https://ncbi.nlm.nih.gov/pubmed/32249768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15578-1
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