Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids

The small GTPases H, K, and NRAS are molecular switches indispensable for proper regulation of cellular proliferation and growth. Several mutations in the genes encoding members of this protein family are associated with cancer and result in aberrant activation of signaling processes caused by a der...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Wiechmann, Svenja, Maisonneuve, Pierre, Grebbin, Britta M., Hoffmeister, Meike, Kaulich, Manuel, Clevers, Hans, Rajalingam, Krishnaraj, Kurinov, Igor, Farin, Henner F., Sicheri, Frank, Ernst, Andreas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2020
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136003/
https://ncbi.nlm.nih.gov/pubmed/32086379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011025
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