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Dual Activation of Phospholipase C-ε by Rho and Ras GTPases
Phospholipase C-ε (PLC-ε) is a highly elaborated PLC required for a diverse set of signaling pathways. Here we use a combination of cellular assays and studies with purified proteins to show that activated RhoA and Ras isoforms directly engage distinct regions of PLC-ε to stimulate its phospholipase...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2573092/ https://ncbi.nlm.nih.gov/pubmed/18765661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805038200 |
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