Dual Activation of Phospholipase C-ε by Rho and Ras GTPases

Phospholipase C-ε (PLC-ε) is a highly elaborated PLC required for a diverse set of signaling pathways. Here we use a combination of cellular assays and studies with purified proteins to show that activated RhoA and Ras isoforms directly engage distinct regions of PLC-ε to stimulate its phospholipase...

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Detaylı Bibliyografya
Asıl Yazarlar: Seifert, Jason P., Zhou, Yixing, Hicks, Stephanie N., Sondek, John, Harden, T. Kendall
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2008
Konular:
Mechanisms of Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573092/
https://ncbi.nlm.nih.gov/pubmed/18765661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805038200
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