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Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes

The lipase activity of most phospholipases C (PLCs) is basally repressed by a highly degenerate and mostly disordered X/Y linker inserted within the catalytic domain. Release of this auto-inhibition is driven by electrostatic repulsion between the plasma membrane and the electronegative X/Y linker....

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Main Authors: Gresset, Aurelie, Hicks, Stephanie N., Harden, T. Kendall, Sondek, John
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975207/
https://ncbi.nlm.nih.gov/pubmed/20807769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166512
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