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Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes
The lipase activity of most phospholipases C (PLCs) is basally repressed by a highly degenerate and mostly disordered X/Y linker inserted within the catalytic domain. Release of this auto-inhibition is driven by electrostatic repulsion between the plasma membrane and the electronegative X/Y linker....
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2975207/ https://ncbi.nlm.nih.gov/pubmed/20807769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166512 |
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