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Auto-inhibition and phosphorylation-induced activation of PLC-γ isozymes
Multiple extracellular stimuli, such as growth factors and antigens, initiate signaling cascades through tyrosine phosphorylation and activation of phospholipase C (PLC)-γ isozymes. Like most other PLCs, PLC-γ1 is basally auto-inhibited by its X-Y linker, which separates the X-and Y-boxes of the cat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3844103/ https://ncbi.nlm.nih.gov/pubmed/23777354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400433b |
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