Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

Direct activation of the human phospholipase C-γ isozymes (PLC-γ1, -γ2) by tyrosine phosphorylation is fundamental to the control of diverse biological processes, including chemotaxis, platelet aggregation, and adaptive immunity. In turn, aberrant activation of PLC-γ1 and PLC-γ2 is implicated in inf...

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Pubblicato in:eLife
Autori principali: Hajicek, Nicole, Keith, Nicholas C, Siraliev-Perez, Edhriz, Temple, Brenda RS, Huang, Weigang, Zhang, Qisheng, Harden, T Kendall, Sondek, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Biochemistry and Chemical Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004563/
https://ncbi.nlm.nih.gov/pubmed/31889510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51700
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