Human colon organoids reveal distinct physiologic and oncogenic Wnt responses

Constitutive Wnt activation upon loss of Adenoma polyposis coli (APC) acts as main driver of colorectal cancer (CRC). Targeting Wnt signaling has proven difficult because the pathway is crucial for homeostasis and stem cell renewal. To distinguish oncogenic from physiological Wnt activity, we have p...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Michels, Birgitta E., Mosa, Mohammed H., Grebbin, Britta M., Yepes, Diego, Darvishi, Tahmineh, Hausmann, Johannes, Urlaub, Henning, Zeuzem, Stefan, Kvasnicka, Hans M., Oellerich, Thomas, Farin, Henner F.
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400532/
https://ncbi.nlm.nih.gov/pubmed/30792186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180823
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars