טוען...
Human colon organoids reveal distinct physiologic and oncogenic Wnt responses
Constitutive Wnt activation upon loss of Adenoma polyposis coli (APC) acts as main driver of colorectal cancer (CRC). Targeting Wnt signaling has proven difficult because the pathway is crucial for homeostasis and stem cell renewal. To distinguish oncogenic from physiological Wnt activity, we have p...
שמור ב:
| הוצא לאור ב: | J Exp Med |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Rockefeller University Press
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6400532/ https://ncbi.nlm.nih.gov/pubmed/30792186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180823 |
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