3D model for CAR‐mediated cytotoxicity using patient‐derived colorectal cancer organoids

Immunotherapy using chimeric antigen receptor (CAR)‐engineered lymphocytes has shown impressive results in leukemia. However, for solid tumors such as colorectal cancer (CRC), new preclinical models are needed that allow to test CAR‐mediated cytotoxicity in a tissue‐like environment. Here, we develo...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Schnalzger, Theresa E, de Groot, Marnix HP, Zhang, Congcong, Mosa, Mohammed H, Michels, Birgitta E, Röder, Jasmin, Darvishi, Tahmineh, Wels, Winfried S, Farin, Henner F
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6576164/
https://ncbi.nlm.nih.gov/pubmed/31036555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100928
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