3D model for CAR‐mediated cytotoxicity using patient‐derived colorectal cancer organoids

Immunotherapy using chimeric antigen receptor (CAR)‐engineered lymphocytes has shown impressive results in leukemia. However, for solid tumors such as colorectal cancer (CRC), new preclinical models are needed that allow to test CAR‐mediated cytotoxicity in a tissue‐like environment. Here, we develo...

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Detaylı Bibliyografya
Yayımlandı:EMBO J
Asıl Yazarlar: Schnalzger, Theresa E, de Groot, Marnix HP, Zhang, Congcong, Mosa, Mohammed H, Michels, Birgitta E, Röder, Jasmin, Darvishi, Tahmineh, Wels, Winfried S, Farin, Henner F
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Resource
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6576164/
https://ncbi.nlm.nih.gov/pubmed/31036555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100928
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