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Covalent Complex of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development
A topoisomerase-DNA transient covalent complex can be a druggable target for novel topoisomerase poison inhibitors that represent a new class of antibacterial or anticancer drugs. Herein, we have investigated molecular features of the functionally important Escherichia coli topoisomerase I (EctopoI)...
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| Publicat a: | ChemMedChem |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7133791/ https://ncbi.nlm.nih.gov/pubmed/32043806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900721 |
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