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Characterization of molecular interactions between E. coli RNA polymerase and topoisomerase I by molecular simulations
Escherichia coli topoisomerase I (EctopoI), a type IA DNA topoisomerase, relaxes the negative DNA supercoiling generated by RNA polymerase (RNAP) during transcription elongation. Due to the lack of structural information on the complex, the exact nature of the RNAP-EctopoI interactions remains unres...
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| Udgivet i: | FEBS Lett |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5014613/ https://ncbi.nlm.nih.gov/pubmed/27448274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12321 |
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