Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells

The prognosis for breast cancer patients diagnosed with brain metastases is poor, with survival time measured merely in months. This can largely be attributed to the limited treatment options capable of reaching the tumor as a result of the highly restrictive blood–brain barrier (BBB). While methods...

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Bibliografiske detaljer
Udgivet i:Nucleic Acid Ther
Main Authors: Macdonald, Joanna, Denoyer, Delphine, Henri, Justin, Jamieson, Adelaide, Burvenich, Ingrid J.G., Pouliot, Normand, Shigdar, Sarah
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc., publishers 2020
Fag:
Original Research Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7133447/
https://ncbi.nlm.nih.gov/pubmed/32027209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0807
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