Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells

The prognosis for breast cancer patients diagnosed with brain metastases is poor, with survival time measured merely in months. This can largely be attributed to the limited treatment options capable of reaching the tumor as a result of the highly restrictive blood–brain barrier (BBB). While methods...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acid Ther
Hauptverfasser: Macdonald, Joanna, Denoyer, Delphine, Henri, Justin, Jamieson, Adelaide, Burvenich, Ingrid J.G., Pouliot, Normand, Shigdar, Sarah
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2020
Schlagworte:
Original Research Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7133447/
https://ncbi.nlm.nih.gov/pubmed/32027209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0807
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