Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells

The prognosis for breast cancer patients diagnosed with brain metastases is poor, with survival time measured merely in months. This can largely be attributed to the limited treatment options capable of reaching the tumor as a result of the highly restrictive blood–brain barrier (BBB). While methods...

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Detalles Bibliográficos
Publicado en:Nucleic Acid Ther
Autores principales: Macdonald, Joanna, Denoyer, Delphine, Henri, Justin, Jamieson, Adelaide, Burvenich, Ingrid J.G., Pouliot, Normand, Shigdar, Sarah
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc., publishers 2020
Materias:
Original Research Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7133447/
https://ncbi.nlm.nih.gov/pubmed/32027209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0807
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