Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells

The prognosis for breast cancer patients diagnosed with brain metastases is poor, with survival time measured merely in months. This can largely be attributed to the limited treatment options capable of reaching the tumor as a result of the highly restrictive blood–brain barrier (BBB). While methods...

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Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Macdonald, Joanna, Denoyer, Delphine, Henri, Justin, Jamieson, Adelaide, Burvenich, Ingrid J.G., Pouliot, Normand, Shigdar, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7133447/
https://ncbi.nlm.nih.gov/pubmed/32027209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0807
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