Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells

The prognosis for breast cancer patients diagnosed with brain metastases is poor, with survival time measured merely in months. This can largely be attributed to the limited treatment options capable of reaching the tumor as a result of the highly restrictive blood–brain barrier (BBB). While methods...

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Dades bibliogràfiques
Publicat a:Nucleic Acid Ther
Autors principals: Macdonald, Joanna, Denoyer, Delphine, Henri, Justin, Jamieson, Adelaide, Burvenich, Ingrid J.G., Pouliot, Normand, Shigdar, Sarah
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc., publishers 2020
Matèries:
Original Research Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7133447/
https://ncbi.nlm.nih.gov/pubmed/32027209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0807
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